psyside
127.0.0.1
- 4 септември 2008
- 30.505
- 31.946
psyside's setup
- Processor & Cooler
- Ryzen 5 [email protected] + PCCooler X5
- Motherboard
- Asrock B450 HDV
- Storage
- 970 EV0 Plus 500GB
- PSU
- Evga 750W BQ
- RAM
- 2x8GB Hyper X Predator@ 3200
- Video card
- Asus RTX Dual EVO 2060 Super
- Case
- CM Masterbox E500 with ODD
- Mouse
- Cooler Master Storm Spawn + Corsair 140/Zalman ZM-F4
- Keyboard
- Logitech G910
- Monitor
- Asus PA328Q Pro Art
- OS
- WIN 10 Pro X64
Apigenin ameliorates genitourinary dysfunction in a type 1 diabetic rat model via Drp1 modulation - Scientific Reports
The present study aimed to explore the potential ameliorative effect of apigenin (APG) against diabetes-associated genitourinary complications in rats. A diabetic rat model was induced by the intraperitoneal injection of streptozotocin (STZ). All experimental animals were treated with vehicle or...
DM is a metabolic disorder with growing global health concerns. Despite the availability of promising treatments, the prevention of tissue damage in the genitourinary system as well as other body systems remains a great challenge. Evidently, STZ is an ideal inducer of diabetes and its complications in rats. It leads to persistent hyperglycemia, which in turn provokes excessive production of ROS with their hazardous effects, especially on mitochondria. The accumulation of evidence indicates that mitochondrial dysfunction contributes to the pathogenesis of diabetic complications
Impressively, previous studies proved that renal pathological and functional changes in the STZ-induced diabetic rat model are very similar to those seen in the human diabetic kidney, making it an ideal model for research. Consequently, genitourinary complications were provoked in rats by STZ.
Impressively, the results of the current study demonstrated that APG injection was associated with restoration of FBG to its normal value, improvement of urinary and serum kidney function’s tests, and secretion of more testosterone. On the tissue level, APG alleviated the hyperglycemia-induced microstructure damage in the genitourinary system. As the PAS area % was reduced, the diameters of seminiferous tubules were increased, and their epithelia linings were greatly restored.
Previous works revealed the astonishing ability of APG to improve diabetic genitourinary complications from a biochemical and histological perspective25,31. Concerning the mechanistic pattern, former studies attributed the benefits of APG to a variety of signaling pathways. Most pathways eventually merge on NF-kB (major inflammatory transcription factor), both in the kidney as well as the testis32,33,34). While, with the purpose of DN improvement, Hou et al.35 anticipated the miR-423-5P-USF2 axis as a molecular network influenced by APG
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